Laboratory techniques in the diagnosis and assessment of hepatitis B virus infection.

نویسندگان

  • J J Gray
  • T G Wreghitt
چکیده

Introduction The discovery of Australia antigen (hepatitis B surface antigen (HBsAg)) by Blumberg in 1965,' its association with serum hepatitis described by Prince in 19682 and the visualisation of the 42 nm infectious hepatitis B virus (HBV) particle by electron microscopy in 19703 led to research into the aetiology, treatment and prevention of serum hepatitis. Further serological markers of HBV and its mode of replication have been described,45 the HBV genome cloned6 and effective vaccines produced.7 HBV infection is endemic in certain geographical areas with approximately 300 million HBsAg carriers worldwide. The carrier rate varies from country to country with 0-2-0.5% in Western Europe and 8-20% in South East Asia. Rates are generally higher in the tropics, amongst males and in urban communities. HBV infection may be symptomatic or asymptomatic and is associated with a wide spectrum of inflammatory liver disease. This ranges from acute to chronic hepatitis and may ultimately lead to cirrhosis or primary hepatocellular carcinoma. In acute symptomatic infections, patients may present with malaise, lethargy, anorexia, headache, mild diarrhoea or upper right quadrant pain followed by jaundice and arthralgia. The detection of HBV markers in the serum of patients with HBV infection is not only important for diagnosis but also for management and predicting the outcome of infection .

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عنوان ژورنال:
  • Genitourinary medicine

دوره 68 4  شماره 

صفحات  -

تاریخ انتشار 1992